THE GENOME SEQUENCE OF BARREN BROME, BROMUS STERILIS L. (POACEAE) [VERSION 2; PEER REVIEW: 2 APPROVED]





A new model mimicking persistent HBV e antigen-negative infection using covalently closed circular DNA in immunocompetent mice.

Despite the availability of an effective vaccine, hepatitis B virus (HBV) infection remains a major health problem.HBV e antigen (HBeAg)-negative strains have become prevalent.Previously, no animal model mimicked the clinical course of HBeAg-negative HBV infection.To establish an HBeAg-negative HBV infection model, the 3.2-kb full-length genome of

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